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HEALTH
Cats 'raise risk of child eczema'

Other studies have
suggested cats can be protective against eczema.
Children who are exposed to cats soon after
birth may have an increased risk of developing eczema, a study
suggests. But the US researchers found that being exposed to two
or more dogs at home produced a slightly protective effect. Eczema
experts said it was too early to draw firm conclusions from the
study, being presented at a US conference. But they said parents
should not remove pets from households as children might go on to
develop allergies later in life when re-exposed to pet hair. The
team led by paediatric expert Esmeralda Morales from the University
of Arizona in Tucson followed 486 children from birth. They asked
parents how many cats and dogs they had in the house when the child
was born. They then followed them up one year on to see which
children had been diagnosed with eczema. Just over 27% of 134
children with cats as pets had eczema by age one, compared with
17.8% of the 286 without cats in their household. But of the 76
children living in houses with two or more dogs, only 13.2% (10) had
eczema, compared to 22% (71 out of 324) of those who did not have
the condition. Research leader Dr Morales said: "Other studies have
found that having cats or dogs at home seems to be protective
against allergic diseases, so we expected to have similar findings.
"Pets are a source of a compound called endotoxin, and if a child is
exposed to endotoxin early in life, the immune system may be skewed
away from developing an allergic profile." She acknowledged the
findings added more questions about pets and asthma and allergies.
Cat allergies
"Since there is a lot of contradictory data out
there already, clearly it's a topic that needs further research,"
she said. The study is being presented at the International
Conference of the American Thoracic Society on Sunday. Dr Sue
Lewis-Jones, consultant dermatologist and British Skin Foundation
spokeswoman, said the study was interesting but that it was too
early to draw conclusions from it. "There are many questions about
the risk of exposure to pets and atopic diseases like eczema. "We
should be cautious about removing pets from the home environment,
because children who are currently tolerant of pet hair may go on to
develop an allergy when re-exposed to animal hair at a later stage,"
said Dr Lewis Jones. "There is a lot of contradictory data around
this subject and it is definitely one that would benefit from
further research."
Rashes
She added that forcibly removing a pet from the
home could have an emotional impact on the child which may in itself
worsen the eczema. A spokeswoman for the Cats Protection League
said: "As the researchers themselves say, most evidence shows that
children who have cats as pets have a reduced risk of developing
asthma and other allergies in later life, so this new piece of
research is rather surprising." She said further research to
disprove this view was needed and that the league would be very
interested in the results. Cat allergy is the most common pet
allergy, affecting up to 40% of asthma sufferers. It is caused by a
tiny protein in a cat's skin flakes and saliva, which is deposited
on the fur when the animal grooms itself by licking. It can trigger
an allergic reaction within minutes if it is breathed in by the
allergy-sufferer. The symptoms usually include itchy eyes, sneezing,
asthma and the skin rashes typical of eczema.
____________________________________________________
UK heart drug policy 'not enough'

The researchers looked at who should
receive medication.
Statins - cholesterol-lowering drugs - should
be prescribed for more people in the UK to be effective in reducing
heart disease, researchers have said. A team from the University
of Manchester studied a group of 1,600 middle-aged men over a
decade. Writing in the journal Heart, they said UK policy would have
prevented only 20 of more than 200 heart attacks and strokes which
happened among the men. But the government said statin prescribing
was increasing annually.
The researchers looked at 1,653 men aged 49 to 65 from
the mid-1980s to the mid-1990s, and recorded how many of them had a
heart attack or stroke. They then calculated how many people would
need to have been given statins to prevent all of these
cardiovascular events, and how the application of current UK,
European and US guidelines would have affected the figures. They
also looked at the potential number of serious disease episodes
which could have been prevented in the population as a whole,
through statin treatment.
Average risk
Over the 10 years there were 212 heart attacks or
stroke among the men. The UK government's National Service Framework
recommendations target those at highest risk, and would require just
14% of the group to be treated. But this only cuts the rate of heart
attack or stroke in the overall population by 9%. European
guidelines resulted in 46% of the group being treated, and a
reduction of 19%. For US guidelines the figures were 60% treated and
around 22% fewer heart attacks and strokes. The researchers, led by
Professor Paul Durrington, said statin treatment will make little
difference to the overall rate of cardiovascular disease unless it
is targeted at all those at average risk - most middle-aged men and
most older women. They added: "Whether cholesterol lowering on such
a scale should be attempted with drugs raises philosophical,
psychological, and economic considerations." Professor Durrington's
team also said more effective national policies on nutrition to
reduce reliance on statins should also be considered.
They
highlighted a "lack of resolve in tackling Britain's unhealthy
diet," which has led to one in three of Europe's obese children
being British. Roger Boyle, the government's National Director for
Coronary Heart Disease, said: "Statin prescribing has been rising by
30% year-on-year in the NHS since publication of the Coronary Heart
Disease NSF in 2000, and we estimate that this is responsible for
saving up to 9,000 lives a year. "Statin prescribing is one key
weapon in the NHS's armoury when in comes to managing cardiovascular
risk. However, this needs to go hand in hand with the massive
programme of work that is under way to change unhealthy lifestyles
and tackle the causes of heart disease, which remains a national
priority." Professor Peter Weissberg, medical director of the
British Heart Foundation, said: "This study suggests that if we are
going to have a real impact on heart attacks and strokes, many more
people should receive statin treatment than current guidelines
suggest. "In fact, guidelines are constantly evolving and the 'goal
posts' are constantly moving towards treating more and more people
at lower and lower risk of a heart attack or stroke." He added:
"There is a real public health dilemma emerging. "This suggests that
we must either treat many more people who are conventionally
considered to be at relatively low risk of a heart attack, or we
must be much more aggressive in our attempts to prevent the disease
from occurring in the first place."
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Scan drug 'boosts cancer therapy'

Chemotherapy can damage
healthy cells.
A drug used to help doctors interpret medical
scans may also help to boost the potency of anti-cancer therapies,
research suggests. Mangafodipir is used as a contrast agent in
hi-tech magnetic resonance imaging (MRI). French researchers found
it increased the cancer-killing ability of some chemotherapy drugs,
while at the same time protecting normal cells. Details are
published in the Journal of the National Cancer Institute.
Many anti-cancer drugs work by increasing the levels of
hydrogen peroxide in tumour cells. Tumour cells are particularly
sensitive to the chemical, and die as a result. However, certain
enzymes in the body can work to protect cells from this kind of
damage, rendering certain cancer drugs less effective. In addition,
the drugs are toxic to normal cells.
Double effect: Mangafodipir was found to
help promote the production of hydrogen peroxide while at the same
time, through different biological mechanisms, protecting healthy
cells from damage. A team from the Groupe hospitalier Cochin-Saint
Vincent de Paul in Paris carried out tests on tumour cells and white
blood cells taken from cancer patients, and white blood cells taken
from healthy patients. Each type of cell was exposed to three
chemotherapy drugs - paclitaxel, oxaliplatin, and 5-fluorouracil -
in the presence and absence of mangafodipir. Mangafodipir was found
to protect the white blood cells taken from both the healthy
volunteers and the cancer patients. The researchers also studied the
effects of mangafodipir on mice with colon cancer who were being
treated with paclitaxel.
Tolerated chemical: They found the drug
protected the animals from infection which could compromise their
immune system, and seemed to increase the cancer-killing potency of
paclitaxel. Henry Scowcroft, cancer information officer at Cancer
Research UK, said: "Mangafodipir was developed in the early nineties
and has a good track record in cancer diagnosis. "We welcome the
discovery that this well-understood and tolerated chemical can
increase the effectiveness of conventional chemotherapy. "These
exciting preliminary results now need to be followed up in further
trials, to make sure that the chemical is as safe when used for
treating cancers as it is for helping detect them."
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